Lead-DBS Methods

Furthermore, the following methods papers document the methodology developed within Lead-DBS

• Electrode localization, normalization of DBS imaging

  • Horn, A., & Kühn, A. A. (2015). Lead-DBS: a toolbox for deep brain stimulation electrode localizations and visualizations. NeuroImage, 107, 127–135.

  • Schönecker, T., Kupsch, A., Kühn, A. A., Schneider, G.-H., & Hoffmann, K. T. (2009). Automated Optimization of Subcortical Cerebral MR Imaging-Atlas Coregistration for Improved Postoperative Electrode Localization in Deep Brain Stimulation. AJNR Am J Neuroradiol, 30(10), 1914–1921.

• Subcortical (clinical/electrophysiology) mapping

  • Horn, A., Neumann, W.-J., Degen, K., Schneider, G.-H., & Kühn, A. A. (2017). Toward an electrophysiological “sweet spot” for deep brain stimulation in the subthalamic nucleus. Human Brain Mapping, 35(3), 5083–14.

  • Schönecker, T., Gruber, D., Kivi, A., Müller, B., Lobsien, E., Schneider, G.-H., et al. (2015). Postoperative MRI localisation of electrodes and clinical efficacy of pallidal deep brain stimulation in cervical dystonia. Journal of Neurology, Neurosurgery, and Psychiatry, 86(8), 833–839.

• Normative connectomes

  • Horn, A., Ostwald, D., Reisert, M., & Blankenburg, F. (2014). The structural-functional connectome and the default mode network of the human brain. NeuroImage, 102 Pt 1, 142–151.

  • Horn, A., & Blankenburg, F. (2016). Toward a standardized structural-functional group connectome in MNI space. NeuroImage, 124(Pt A), 310–322.

  • Application in
    • Horn, A., Neumann, W.-J., Degen, K., Schneider, G.-H., & Kühn, A. A. (2017). Toward an electrophysiological “sweet spot” for deep brain stimulation in the subthalamic nucleus. Human Brain Mapping, 35(3), 5083–14.

    • Horn, A., Kühn, A. A., Merkl, A., Shih, L., Alterman, R., & Fox, M. (2017). Probabilistic conversion of neurosurgical DBS electrode coordinates into MNI space. NeuroImage, 150, 395–404.

    • Ewert, S., Plettig, P., Chakravarty, M. M., Kuehn, A. A., & Horn, A. (2016). Toward defining deep brain stimulation targets in MNI space: A subcortical atlas based on multimodal MRI, histology and structural connectivity. bioRxiv, 062851.

• AC/PC to MNI conversion
  • Horn, A., Kühn, A. A., Merkl, A., Shih, L., Alterman, R., & Fox, M. (2017). Probabilistic conversion of neurosurgical DBS electrode coordinates into MNI space. NeuroImage, 150, 395–404.